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Metabolic syndrome: Nutri-epigenetic cause or consequence?
Alfonso D Silva-Ochoa1,2, Erick Velasteguí1,3, Isaac B Falconí1
1Laboratorio para Investigaciones Biomédicas, Facultad de Ciencias de la Vida, Escuela Superior Politécnica del Litoral, ESPOL, Campus Gustavo Galindo Km. 30.5 Vía Perimetral, P.O. Box 09-01-5863, Guayaquil, Ecuador.
Heliyon
|November 13, 2023
Summary
Epigenetics plays a role in metabolic syndrome, a condition increasing risks for obesity and cardiovascular disease. This review examines studies linking epigenetic changes to metabolic syndrome, especially in developing nations.
Area of Science:
- Genetics and Epigenetics
- Metabolic Disorders
- Public Health
Background:
- Metabolic syndrome is a complex condition involving genetic and environmental factors.
- It elevates the risk of obesity, hyperglycemia, dyslipidemia, hypertension, stroke, and cardiovascular disease.
- Understanding its origins is crucial for public health, particularly in developing countries.
Purpose of the Study:
- To review high-impact studies investigating the link between epigenetics and metabolic syndrome.
- To compare study populations, methylation effects, and research methodologies.
- To discuss global epidemiological data on metabolic syndrome incidence.
Main Methods:
- Literature review of high-impact scientific studies.
- Comparative analysis of study populations and epigenetic (methylation) effects.
- Synthesis of global statistical data on metabolic syndrome prevalence.
Main Results:
- Identified key epigenetic mechanisms associated with metabolic syndrome.
- Highlighted variations in findings based on study populations and methods.
- Provided an overview of the global burden of metabolic syndrome, with emphasis on developing countries.
Conclusions:
- Epigenetic factors are significantly implicated in the development of metabolic syndrome.
- Further research is needed to elucidate specific epigenetic markers and their causal roles.
- Addressing metabolic syndrome requires a global public health strategy, considering regional disparities.
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