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RIPK1 and RIPK3 inhibitors: potential weapons against inflammation to treat diabetic complications

Dan Ke1,2, Zhen Zhang2,3, Jieting Liu1,2

  • 1College of Life Sciences, Mudanjiang Medical University, Mudanjiang, China.

Frontiers in Immunology
|November 13, 2023
PubMed

Insights

Diabetes complications cause significant disability and death. Targeting receptor-interacting serine/threonine-kinase-1 (RIPK1) and RIPK3 may offer new anti-inflammatory treatments for these conditions.

Area of Science:

  • Immunology and Metabolism
  • Inflammation and Disease Pathogenesis

Background:

  • Diabetes mellitus is a metabolic disorder defined by chronic hyperglycemia.
  • Sustained metabolic stress in diabetes triggers inflammation, leading to severe complications like diabetic nephropathy, ophthalmopathy, and cardiovascular issues.
  • These complications are major causes of mortality and disability worldwide.

Purpose of the Study:

  • To review current research on the mechanisms of action and drug development of RIPK1 and RIPK3.
  • To explore the potential of targeting RIPK1 and RIPK3 as anti-inflammatory therapeutic agents for diabetic complications.

Main Methods:

  • Literature review of current research on RIPK1 and RIPK3.
  • Analysis of their role in chronic inflammation and immunity.
  • Examination of their relevance to diabetic complications.

Main Results:

  • RIPK1 and RIPK3 are key regulators of inflammatory pathways.
  • Their involvement in chronic inflammation is significant.
  • Research is exploring selective inhibitors for therapeutic applications.

Conclusions:

  • RIPK1 and RIPK3 are pivotal in chronic inflammation and immunity.
  • Targeting RIPK1 and RIPK3 presents a promising avenue for developing novel anti-inflammatory therapies for diabetic complications.
  • Further research into selective inhibitors could offer new treatment strategies.
Keywords:
diabetesdiabetic complicationsinflammationreceptor interacting protein kinaseregulatory cell death

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