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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

317
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
317
T Cell Types and Functions01:24

T Cell Types and Functions

1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Immunological Memory01:23

Immunological Memory

630
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
630
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

753
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
753
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

999
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Related Experiment Video

Updated: Jul 11, 2025

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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Memory regulatory T cells in pregnancy.

Zeyang Chen1,2, Yanan Zhang3, Joanne Kwak-Kim4,5

  • 1School of Medicine, Qingdao University, Qingdao, China.

Frontiers in Immunology
|November 13, 2023
PubMed
Summary

Memory regulatory T cells (Tregs) are crucial for immune tolerance during pregnancy. Impaired memory Treg function is linked to pregnancy complications, highlighting their therapeutic potential.

Keywords:
gestational diabetes mellitusmemory regulatory T cellspreeclampsiapregnancyrecurrent pregnancy lossreproductive immunology

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Area of Science:

  • Reproductive Immunology
  • Immunology
  • Maternal-Fetal Medicine

Background:

  • Successful pregnancy relies on maternal immune tolerance to semi-allogeneic embryos.
  • An overactive maternal immune response can lead to embryo rejection and adverse pregnancy outcomes.
  • Regulatory T cells (Tregs) are key to immune homeostasis and suppressing excessive immune responses.

Purpose of the Study:

  • To review the differentiation, activation, and characteristics of memory Tregs.
  • To elucidate the critical role of memory Tregs at the maternal-fetal interface in successful pregnancy.
  • To explore the correlation between memory Treg dysfunction and pregnancy complications, and potential therapeutic strategies.

Main Methods:

  • Literature review focusing on memory Treg differentiation and function in pregnancy.
  • Analysis of the association between memory Tregs and pregnancy complications.
  • Investigation of potential immunotherapies targeting memory Treg abnormalities.

Main Results:

  • Memory Tregs possess long-term survival and potent immune regulatory capabilities.
  • Impaired memory Treg function is associated with conditions like preeclampsia, gestational diabetes mellitus, and recurrent pregnancy loss.
  • Understanding memory Tregs offers novel diagnostic and therapeutic targets for pregnancy-associated diseases.

Conclusions:

  • Memory Tregs are vital for maintaining immune tolerance and successful pregnancy.
  • Dysfunctional memory Tregs contribute to various pregnancy complications.
  • Restoring memory Treg function presents a promising therapeutic avenue for managing pregnancy-associated diseases.