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Overview of Protein Metabolism01:21

Overview of Protein Metabolism

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Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
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Inborn Errors of Metabolism01:20

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Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Related Experiment Video

Updated: Jul 11, 2025

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

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Protein S Deficiency: A Case Report.

Shirley M Gandhi1, Pruthvi Patel2, James R Conner3

  • 1Internal Medicine-Pediatrics, Alabama College of Osteopathic Medicine, Dothan, USA.

Cureus
|November 13, 2023
PubMed
Summary
This summary is machine-generated.

Protein S deficiency can lead to dangerous blood clots. This case highlights a rare presentation and the importance of monitoring protein S levels for patients on anticoagulants.

Keywords:
anti-coagulationbleeding riskhematologicalhypercoagulable stateroutine screening

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Area of Science:

  • Hematology
  • Internal Medicine
  • Pathology

Background:

  • Protein S is a crucial glycoprotein regulating blood coagulation, preventing hypercoagulable states.
  • Protein S deficiency necessitates anticoagulant therapy due to the absence of a definitive cure.
  • Imbalances in the hematological system can result in severe complications like thrombosis and pulmonary embolism.

Observation:

  • A 74-year-old female presented with respiratory failure, UTI, and pneumonia following collapse.
  • MRI revealed thrombus formation in the distal right transverse and sigmoid sinuses.
  • Hematologic workup confirmed normal homocysteine, fibrinogen, and protein C levels.

Findings:

  • The patient exhibited significantly reduced protein S levels, measured at 24%.
  • This case illustrates a rare clinical manifestation of protein S deficiency.
  • Diagnostic findings underscore the complexity of hematological disorders.

Implications:

  • Highlights the critical role of protein S in preventing thrombotic events.
  • Emphasizes the need for vigilant monitoring and management of protein S-deficient patients.
  • Underscores the importance of routine follow-up for maintaining patient health and preventing complications.