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Related Concept Videos

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Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Related Experiment Video

Updated: Jul 11, 2025

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
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Recurrent Soft Tissue Infections Associated With Burosumab Therapy in X-Linked Hypophosphatemic Rickets.

Sean Ho Yoon1, Pasquale Passarella1

  • 1Department of Endocrinology, Albany Medical Center, Albany, NY 12208, USA.

JCEM Case Reports
|November 13, 2023
PubMed
Summary
This summary is machine-generated.

X-linked hypophosphatemic rickets (XLH) treatment with burosumab may increase infection risk. Discontinuing burosumab in an XLH patient resolved recurrent soft tissue infections, suggesting a potential link.

Area of Science:

  • Immunology
  • Genetics
  • Pharmacology

Background:

  • X-linked hypophosphatemic rickets (XLH) is a genetic disorder causing phosphate wasting and poor bone mineralization due to elevated FGF23.
Keywords:
X-linked hypophosphatemic ricketsburosumabfibroblast growth factorsoft tissue infection

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  • Burosumab, an FGF23 inhibitor, improves XLH outcomes but its impact on immunity is unclear.