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Related Experiment Videos

[Thermotolerance in normal and tumor tissues].

K Ohtsuka

    Gan No Rinsho. Japan Journal of Cancer Clinics
    |October 1, 1986
    PubMed
    Summary

    Thermotolerance, an increased resistance to heat, occurs in normal and tumor tissues. This phenomenon is linked to heat shock proteins (HSPs), particularly HSP 70, which can be detected in various tissues.

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    Area of Science:

    • Oncology
    • Biochemistry
    • Cell Biology

    Context:

    • Thermotolerance, or acquired heat resistance, is observed in both normal and tumor tissues.
    • Tumor tissue pH is typically lower than normal tissue, potentially affecting thermotolerance development.
    • Heat shock proteins (HSPs) are known to be involved in thermotolerance.

    Purpose:

    • To investigate the kinetics and magnitude of thermotolerance in normal versus tumor tissues.
    • To explore the correlation between thermotolerance and heat shock protein synthesis, specifically HSP 70.
    • To establish a method for quantifying HSP 70 in various tissue types.

    Summary:

    • Thermotolerance magnitude in tumors is comparable to normal tissues, despite lower tumor pH.
    • The development of thermotolerance is strongly correlated with the enhanced synthesis of heat shock proteins (HSPs).
    • HSP 70 was purified, and an antiserum was generated, enabling its quantitative detection in cultured cells and tissues via immunoblotting.

    Impact:

    • Provides a foundation for understanding thermotolerance in cancer therapy.
    • Highlights the role of HSP 70 as a potential biomarker for heat treatment response.
    • Enables further research into modulating HSP 70 for improved hyperthermia efficacy in tumors.

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