[In search of the optimal heat interval in clinical hyperthermia]

The influence of thermotolerance on clinical hyperthermia was reviewed and analysed on CR ratio by weekly heat fractionation numbers. In combined radiotherapy (40 Gy greater than or equal to), 434 cases, CR ratio was 74%, 60%, 40% and 37% for each 1, 2, 3 and 5 heat fractions weekly. In group of hyperthermia alone, consisting of 162 cases CR ratio was 25%, 14% and 0% for 2, 3 and 5 weekly heat fractions respectively. That of radiotherapy alone (40 Gy, greater than or equal to), 168 cases, was 40%. In view of CR ratio, as heat fractions decreases weekly, thermotolerance plays increasingly negative role on treatment effect on both hyperthermia alone and combined radiotherapy group.