Related Experiment Video

Updated: Jul 11, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Published on: March 27, 2020

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Emerging roles of activating transcription factor 2 in the development of breast cancer: a comprehensive review

Ahmed Amarah1, Ahmed Adel Elsabagh1, Amr Ouda1

  • 1College of Medicine, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar.

Precision Clinical Medicine
|November 13, 2023
PubMed

Insights

Activating transcription factor 2 (ATF2) has a dual role in breast cancer, acting as both an oncogene and a tumor suppressor. Research is ongoing to clarify its function and develop targeted therapies for endocrine resistance.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Activating transcription factor 2 (ATF2) is a DNA-binding protein crucial for cellular functions.
  • Its precise role in breast cancer development and progression remains debated.
  • ATF2 influences cellular proliferation, apoptosis, and DNA repair mechanisms.

Purpose of the Study:

  • To review current literature on the role of ATF2 in breast cancer.
  • To explore the association between ATF2 and endocrine therapy resistance.
  • To discuss ongoing clinical trials targeting ATF2 pathways.

Main Methods:

  • Narrative review of published studies.
  • Analysis of research on ATF2's impact on estrogen receptor (ER) activity and tamoxifen sensitivity.
  • Exploration of ATF2's role in DNA repair and drug resistance.

Main Results:

  • Studies present conflicting evidence: ATF2 may act as an oncogene or a tumor suppressor.
  • ATF2 influences ER expression and activity, potentially impacting tamoxifen response.
  • Ongoing trials investigate ATF2-targeting therapies for breast cancer treatment and overcoming resistance.

Conclusions:

  • The multifaceted role of ATF2 in breast cancer requires further elucidation.
  • Understanding ATF2's dual functions is key to developing novel therapeutic strategies.
  • Targeting ATF2 pathways may offer new avenues for treating breast cancer and endocrine resistance.
Keywords:
ATF2breast canceroncogene

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