Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CDK8 inhibition induces Mediator trapping and impairment of the EWSR1::FLI1 transcriptional program in Ewing sarcoma.

Cancer discovery·2026
Same author

Occurrence and potential sources of greenhouse gases at Wuzhen, a typical ancient water town in Eastern China.

Environmental monitoring and assessment·2026
Same author

Incipient Constituents: Phonesthemes Facilitate Word Processing in English.

Open mind : discoveries in cognitive science·2026
Same author

Loss of heterozygosity exposes germline mutations in complex I and drives Warburg metabolism in oncocytic carcinoma of the thyroid.

Science advances·2026
Same author

Self-Assembed G-Quadruplex Nanowires for Energy Transfer over Micrometers.

Biomacromolecules·2026
Same author

A Clinically Integrated Pediatric Patient-Derived Xenograft Program Enables Evaluation of Cohort and Patient-Specific Biology and Therapeutic Strategies.

Cancer research·2026

Related Experiment Video

Updated: Jul 11, 2025

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

9.3K

Osteosarcoma Explorer: A Data Commons With Clinical, Genomic, Protein, and Tissue Imaging Data for Osteosarcoma

Donghan M Yang1,2, Qinbo Zhou1, Lauren Furman-Cline3

  • 1Quantitative Biomedical Research Center, Peter O'Donnell Jr School of Public Health, The University of Texas Southwestern Medical Center, Dallas, TX.

JCO Clinical Cancer Informatics
|November 13, 2023
PubMed
Summary

Researchers developed the Osteosarcoma Explorer (OSE), a data commons integrating diverse data types for pediatric osteosarcoma research. This platform enhances data accessibility and analysis for this rare bone cancer.

More Related Videos

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.2K
Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
07:43

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

2.8K

Related Experiment Videos

Last Updated: Jul 11, 2025

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

9.3K
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.2K
Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
07:43

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

2.8K

Area of Science:

  • Biomedical Informatics
  • Oncology
  • Data Science

Background:

  • Osteosarcoma research is fragmented due to siloed data across clinical, genomic, proteomic, and imaging sources.
  • Effective data integration is crucial for advancing understanding and treatment of osteosarcoma.

Purpose of the Study:

  • To develop a comprehensive, integrated data commons for pediatric osteosarcoma research.
  • To create a user-friendly platform for data exploration and analysis.

Main Methods:

  • Collected and integrated clinical, molecular profiling, and tissue imaging data from 573 pediatric osteosarcoma patients.
  • Developed a common data model and relational database for harmonized data storage.
  • Built the Osteosarcoma Explorer (OSE) web portal with data exploration and analytics functionalities.

Main Results:

  • The Osteosarcoma Explorer (OSE) was launched in 2021, providing access to integrated osteosarcoma data.
  • OSE offers features like Cohort Discovery, Patient Dashboard, Image Visualization, and Online Analysis.
  • OSE is the largest pediatric osteosarcoma data commons, demonstrating successful data integration and user engagement.

Conclusions:

  • The Osteosarcoma Explorer (OSE) provides a valuable online platform for integrated osteosarcoma data analysis.
  • The developed framework supports expansion to new data modalities and sources, facilitating future research.