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Multiple Comparison Tests

Multiple Comparison Tests

Multiple comparison test, abbreviated as MCT, is a post hoc analysis generally performed after comparing multiple samples with one or more tests. An MCT will help identify a significantly different sample among multiple samples or a factor among multiple factors.
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...

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Development and Pilot of an Mpox Severity Scoring System.

Jason Zucker¹, Jacob McLean¹, Simian Huang¹

¹Division of Infectious Diseases, Vagelos College of Physicians and Surgeons, Columbia University, NewYork, New York.

The Journal of Infectious Diseases

|November 13, 2023

Summary

A new Mpox Severity Scoring System (MPOX-SSS) helps identify risk factors for severe illness. Higher scores were observed in patients treated with tecovirimat, with delayed symptom onset, and lower CD4 counts.

Keywords:

MPOX-SSS infectious disease monkeypox mpox severity scoring system

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Area of Science:

Virology
Epidemiology
Clinical Medicine

Background:

Clinical severity scores are crucial for understanding risk factors in infectious disease outbreaks.
The 2022 multinational mpox (monkeypox) outbreak, caused by clade IIb virus, necessitated tools for assessing disease severity.

Purpose of the Study:

To develop and validate a clinical severity scoring system for mpox.
To identify risk factors associated with severe mpox illness using the developed scoring system.

Main Methods:

Development of a 7-item Mpox Severity Scoring System (MPOX-SSS) using initial variables.
Refinement of variables based on data availability and parameter correlation.
Application of MPOX-SSS to the first 200 mpox patients and serial evaluations.

Main Results:

The MPOX-SSS showed higher scores in patients treated with tecovirimat.
Higher scores were associated with symptom onset >3 days after presentation and CD4 counts <200 cells/mm3.
Serial MPOX-SSS scores correlated with clinical observations and demonstrated good discrimination over time.

Conclusions:

The pilot MPOX-SSS effectively distinguishes severity and identifies patients at higher risk.
The scoring system aids in understanding risk factors for severe mpox illness.
MPOX-SSS demonstrates utility in clinical assessment and monitoring of mpox patients.