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Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Overview of Lipid Metabolism01:24

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Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
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Lipids: Dietary Sources and Requirements01:18

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Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
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Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

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Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
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Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

559
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
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Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Related Experiment Video

Updated: Jul 11, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Dyslipidemia in diabetes.

Sanjay Kalra1, Nishant Raizada2

  • 1Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India.

Indian Heart Journal
|November 13, 2023
PubMed
Summary

Diabetic dyslipidemia, characterized by abnormal cholesterol levels, significantly increases cardiovascular disease risk. Effective management involves lifestyle changes and medications like statins, ezetimibe, and novel therapies to reduce cardiovascular events.

Keywords:
Diabetes mellitusDyslipidaemiaStatins

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Area of Science:

  • Endocrinology
  • Cardiology
  • Metabolic Disorders

Background:

  • Diabetes mellitus frequently leads to cardiovascular diseases (CVD), a major cause of death in diabetic patients.
  • Diabetic dyslipidemia typically involves low HDL cholesterol, high triglycerides, and atherogenic small, dense LDL particles.
  • Risk factors include genetics, obesity, inactivity, alcohol, and poor glucose control.

Purpose of the Study:

  • To review the characteristics and management of dyslipidemia in diabetes mellitus.
  • To highlight the importance of dyslipidemia management in reducing cardiovascular risk.
  • To discuss current and emerging therapeutic strategies.

Main Methods:

  • Literature review of diabetic dyslipidemia and its management.
  • Analysis of non-pharmacological and pharmacological treatment options.
  • Discussion of novel therapeutic agents and targets.

Main Results:

  • Non-pharmacological approaches (diet, exercise, weight loss) are crucial.
  • Statins are the primary pharmacotherapy, effective even with normal LDL due to small dense LDL particles.
  • Combination therapy (ezetimibe/statins) and novel agents (bempedoic acid, PCSK9 inhibitors) offer additional treatment options.

Conclusions:

  • Optimal management of dyslipidemia is essential for treating diabetes mellitus.
  • LDL cholesterol targets are based on individual cardiovascular risk.
  • The role of triglyceride-lowering pharmacotherapy in mild-to-moderate hypertriglyceridemia with diabetes requires further consideration.