Related Experiment Video
Updated: Jul 11, 2025

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
Published on: March 10, 2020
Sociodemographic profile associated with congenital heart disease among infants <1 year old
Michelle Tran1, Anna Miner1, Carlin Merkel2
1Department of Population and Public Health Sciences, Keck School of Medicine of University of Southern California (KSOM USC) and Division of Research on Children, Youth, and Families, The Saban Research Institute, Children's Hospital Los Angeles (CHLA), Los Angeles, CA, United States of America.
Insights
Maternal education levels were linked to congenital heart disease (CHD) incidence in a study of US infants. Identifying at-risk mothers may help reduce health disparities associated with CHD.
Area of Science:
- Pediatric Cardiology
- Public Health
- Sociodemographics
Background:
- Congenital heart disease (CHD) affects numerous US newborns annually.
- Research on sociodemographic impacts on CHD health outcomes exists, but its effect on CHD incidence is unclear.
- Understanding these factors is crucial for addressing health disparities.
Purpose of the Study:
- To explore the sociodemographic profile associated with congenital heart disease (CHD).
- To identify potential preventative measures for CHD.
- To address health disparities related to race and social determinants of health in CHD.
Main Methods:
- Secondary analysis of longitudinal data from 39 infants with CHD and 30 healthy controls.
- Sociodemographic data collected via questionnaire.
- Pearson's chi-square/Fisher's exact tests used for association analysis.
Main Results:
- A statistically significant difference in maternal education was observed between infants with CHD and healthy controls (p=0.004).
Conclusions:
- Maternal education is associated with congenital heart disease (CHD).
- Further research is needed to identify predictive sociodemographic factors for CHD incidence.
- Interventions targeting identified factors may decrease CHD health disparities.
Purpose:
Congenital heart disease affects thousands of newborns each year in the United States. Previous United States-based research has explored how sociodemographic factors may impact health outcomes in infants with congenital heart disease; however, their impact on the incidence of congenital heart disease is unclear. We explored the sociodemographic profile related to congenital heart disease to help address health disparities that arise from race and social determinants of health. Defining the sociodemographic factors associated with congenital heart disease will encourage implementation of potential preventative measures.
Design And Methods:
We conducted a secondary analysis of longitudinally collected data comparing 39 infants with congenital heart disease and 30 healthy controls. We used a questionnaire to collect sociodemographic data. Pearson's chi-square test/Fisher's exact tests analyzed the associations among different sociodemographic factors between infants with congenital heart disease and healthy controls.
Results:
We found a statistically significant difference in maternal education between our 2 groups of infants (p = 0.004).
Conclusion:
Maternal education was associated with congenital heart disease. Future studies are needed to further characterize sociodemographic factors that may predict and impact the incidence of congenital heart disease and to determine possible interventions that may help decrease health disparities regarding the incidence of congenital heart disease.
Practice Implications:
Understanding the associations between maternal sociodemographic factors and infant congenital heart disease would allow clinicians to identify mothers at higher risk of having an infant with congenital heart disease.
Related Concept Videos
Heart Failure IV: Classification and Diagnostic Evaluation
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Mitral Stenosis I: Introduction
Cardiomyopathy I: Introduction and Classification
Cardiopulmonary Resuscitation I: Adult
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

