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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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DNA as a Genetic Template02:05

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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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Genetic Material01:20

Genetic Material

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Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.
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The Central Dogma01:20

The Central Dogma

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The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
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Related Experiment Video

Updated: Jul 11, 2025

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
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The Imageable Genome.

Pablo Jané1,2, Xiaoying Xu3, Vincent Taelman3

  • 1University of Geneva, Geneva, Switzerland.

Nature Communications
|November 13, 2023
PubMed
Summary
This summary is machine-generated.

Researchers identified the "Imageable Genome," genes detectable by molecular imaging. This discovery, using AI and RNA-seq data, aids in developing new diagnostics and therapies for various human diseases.

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Area of Science:

  • Molecular Medicine
  • Genomics
  • Medical Imaging

Background:

  • Molecular medicine aims to translate molecular discoveries into clinical applications for disease diagnostics and therapies.
  • Efficiently bridging molecular findings with clinical practice remains a challenge.

Purpose of the Study:

  • To introduce the concept of the Imageable Genome: the subset of the human genome detectable through molecular imaging.
  • To develop a pipeline for linking genes to diseases and identifying relevant molecular imaging methods.

Main Methods:

  • A hybrid human-Artificial Intelligence (AI) pipeline was employed to analyze gene expression and disease relevance.
  • The Imageable Genome was cross-referenced with RNA-sequencing (RNA-seq) data from over 60,000 individuals.

Main Results:

  • Identification of diagnostic, prognostic, and predictive imageable genes across a spectrum of major human diseases.
  • The Imageable Genome comprises genes whose expression changes are critical during disease development and progression.

Conclusions:

  • The Imageable Genome provides a foundation for developing novel molecular imaging tools.
  • These new tools have the potential to significantly enhance the understanding, diagnosis, and management of human diseases.