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The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy
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Intrahepatic cholestasis of pregnancy: insights into pathogenesis and advances in omics studies

Mi Tang1,2, Liling Xiong3, Jianghui Cai4,2

  • 1GCP Institution, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.

Hepatology International
|November 13, 2023
PubMed

Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-specific liver disease. It is characterized by pruritus, abnormal liver function and elevated total bile acid (TBA) levels, increasing the risk of maternal and fetal adverse outcomes. Its etiology remains poorly elucidated. Over the years, various omics techniques, including metabolomics, microbiome, genomics, etc., have emerged with the advancement of bioinformatics, providing a new direction for exploring the pathogenesis, diagnosis and treatment of ICP. In this review, we first summarize the role of bile acids and related components in the pathogenesis of ICP and then further illustrate the results of omics studies.

Keywords:
Bile acidBile acid receptorGeneGenomicsGut microbiotaHormoneIntrahepatic cholestasis of pregnancyLipidMetabolomicsMicrobiome

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