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Updated: Jul 11, 2025
Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
Published on: September 27, 2024
Knowledge mapping of programmed cell death in osteonecrosis of femoral head: a bibliometric analysis (2000-2022)
Xue-Zhen Liang1,2, Nan Li3, Jin-Lian Chai4
1First College of Clinical Medicine, Orthopaedic Microsurgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jingshi Road, 16369, Jinan, 250014, Shandong, China.
Background:
Osteonecrosis of the femoral head (ONFH) is a common, refractory and disabling disease of orthopedic department, which is one of the common causes of hip pain and dysfunction. Recent studies have shown that much progress has been made in the research of programmed cell death (PCD) in ONFH. However, there is no bibliometric analysis in this research field. This study aims to provide a comprehensive overview of the knowledge structure and research hot spots of PCD in ONFH through bibliometrics.
Method:
The literature search related to ONFH and PCD was conducted on the Web of Science Core Collection (WoSCC) database from 2002 to 2021. The VOSviewers, "bibliometrix" R package and CiteSpace were used to conduct this bibliometric analysis.
Results:
In total, 346 articles from 27 countries led by China and USA and Japan were included. The number of publications related to PCD in ONFH is increasing year by year. Shanghai Jiao Tong University, Xi An Jiao Tong University, Wuhan University and Huazhong University of Science and Technology are the main research institutions. Molecular Medicine Reports is the most popular journal in the field of PCD in ONFH, and Clinical Orthopaedics and Related Research is the most cocited journal. These publications come from 1882 authors among which Peng Hao, Sun Wei, Zhang Chang-Qing, Zhang Jian and Wang Kun-zheng had published the most papers and Ronald S Weinstein was cocited most often. Apoptosis, osteonecrosis, osteonecrosis of the femoral head, glucocorticoid and femoral head appeared are the main topics the field of PCD in ONFH. Autophagy was most likely to be the current research hot spot for PCD in ONFH.
Conclusion:
This is the first bibliometric study that comprehensively summarizes the research trends and developments of PCD in ONFH. This information identified recent research frontiers and hot directions, which will provide a reference for scholars studying PCD in ONFH.
Insights
This bibliometric analysis reveals research trends in programmed cell death (PCD) for osteonecrosis of the femoral head (ONFH). Autophagy emerges as a key research hotspot in this disabling orthopedic condition.
Area of Science:
- Orthopedics
- Cell Biology
- Biomedical Research
Background:
- Osteonecrosis of the femoral head (ONFH) is a significant orthopedic condition causing hip pain and dysfunction.
- Recent research has advanced understanding of programmed cell death (PCD) in ONFH.
- A bibliometric analysis was lacking to synthesize this growing body of research.
Conclusions:
- This is the first bibliometric study to summarize research on PCD in ONFH.
- Identifies current research frontiers and hot directions for future investigation.
- Provides a valuable reference for researchers in the field of ONFH and PCD.
