KAAACI Guidelines for Allergen Immunotherapy

Area of Science:

• Immunology and Allergy
• Clinical Practice Guidelines

Background:

• Allergen immunotherapy (AIT) is a crucial treatment for allergic diseases, inducing tolerance to allergens.
• Growing discovery of AIT candidates and new therapeutic approaches necessitate updated practice guidelines.
• This guideline updates the 2010 Korean Academy of Asthma Allergy and Clinical Immunology recommendations.

Purpose of the Study:

• To provide updated expert recommendations for allergen immunotherapy (AIT).
• To establish uniform practice guidelines for AIT based on an extensive literature review.
• To address key aspects of AIT, including mechanisms, efficacy, and patient management.

Main Methods:

• Expert opinion from specialists in allergy, pediatrics, and otorhinolaryngology.
• Comprehensive literature review of existing AIT research and guidelines.
• Development of updated recommendations for clinical AIT practice.

Main Results:

• The guideline covers essential AIT knowledge: mechanisms, clinical efficacy, patient selection, allergen extract selection, dosing, and adverse reaction management.
• Special considerations for pediatric AIT are included.
• Sublingual immunotherapy guidelines will be detailed in a separate publication.

Conclusions:

• Updated guidelines are essential for the consistent and effective application of AIT.
• These recommendations aim to standardize AIT practices for various allergic conditions.
• The guideline provides a comprehensive resource for clinicians managing patients undergoing AIT.