A New Scoring System to Differentiate Bladder Cancer from Intravesical Prostatic Protrusion in the Bladder Neck:...

Area of Science:

• Urology
• Oncology
• Medical Diagnostics

Background:

• Differentiating bladder cancer (BCa) from intravesical prostate protrusion (IPP) can be challenging with imaging alone.
• Accurate differentiation is crucial for appropriate patient management and treatment.

Purpose of the Study:

• To identify predictive criteria for bladder cancer in cases indistinguishable from IPP.
• To develop a novel scoring system, the BCa-IPP score, for improved diagnostic accuracy.

Main Methods:

• Retrospective analysis of 174 patients with bladder neck lesions.
• Comparison of laboratory (hemoglobin, PSA) and ultrasound (PV, BWT, LH, LW/B ratio) parameters between BCa and benign prostate lesion groups.
• Development of the BCa-IPP scoring system based on multivariate analysis and odds ratios.

Main Results:

• All analyzed factors showed an Area Under the Curve (AUC) >0.7 in ROC analysis.
• The developed BCa-IPP scoring system achieved a high AUC of 0.954.
• Optimal cut-off score of 10 demonstrated 93% sensitivity and 85% specificity.

Conclusions:

• The BCa-IPP scoring system, utilizing non-invasive laboratory and ultrasound findings, offers high predictive value.
• This easily applicable scoring system can reliably differentiate bladder cancer from benign prostate lesions in clinical settings.