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Galectin-3 as a Prognostic Biomarker in Patients with First Acute Myocardial Infarction without Heart Failure

Rada M Vucic1,2, Olivera M Andrejic3, Dragana Stokanovic4

  • 1Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica Street 69, 34000 Kragujevac, Serbia.

Diagnostics (Basel, Switzerland)
|November 14, 2023
PubMed

Insights

Galectin-3 (Gal-3) plasma levels measured within 24 hours of acute myocardial infarction (AMI) onset predict major adverse cardiovascular events (MACE). Aortic root Gal-3 concentration is a strong prognostic marker for six-month MACE in AMI patients.

Area of Science:

  • Cardiology
  • Biomarker Discovery
  • Clinical Prognostics

Background:

  • Galectin-3 (Gal-3) is implicated in cardiac remodeling post-acute myocardial infarction (AMI).
  • Prognostic markers are crucial for improving survival and quality of life in AMI patients.

Purpose of the Study:

  • To evaluate Galectin-3 (Gal-3) plasma concentration as a prognostic biomarker in patients with acute myocardial infarction (AMI).
  • To assess the predictive value of Gal-3 for major adverse cardiovascular events (MACE) within six months post-AMI.

Main Methods:

  • Included 59 patients with AMI and preserved ejection fraction.
  • Measured Gal-3 plasma concentration within 24 hours of chest pain onset from multiple sites (aortic root, femoral/radial artery, coronary sinus, cubital vein).
  • Evaluated Major Adverse Cardiovascular Events (MACE) at six-month follow-up.

Main Results:

  • Twenty patients (34%) experienced MACE at six months post-AMI.
  • Aortic root and femoral/radial artery Gal-3 concentrations independently predicted six-month MACE.
  • Aortic root Gal-3 concentration (cut-off ≥ 10.86 ng/mL) showed superior predictive value for MACE or death (AUC 0.858) compared to femoral/radial artery measurements.

Conclusions:

  • Galectin-3 plasma concentration, particularly from the aortic root, measured during coronary angiography within 24 hours of chest pain onset, is a valuable prognostic biomarker in AMI patients.
  • This finding aids in identifying patients at higher risk for adverse cardiovascular events within six months post-AMI.
Abstract

Keywords:
acute myocardial infarctiongalectin-3major adverse cardiovascular events

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