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Albuminuria Is Affected by Urinary Tract Infection: A Comparison between Biochemical Quantitative Method and
Yi-Ju Chou1, Chun-Chun Yang2, Shang-Jen Chang3
1Division of Urology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 23142, Taiwan.
Diagnostics (Basel, Switzerland)
|November 14, 2023
Summary
Urinary tract infections (UTIs) can impact the accuracy of automated urine reagent strip tests for albuminuria detection. Treating UTIs is crucial before using these tests for reliable albuminuria screening.
Area of Science:
- Clinical chemistry
- Urology
- Diagnostic accuracy
Background:
- Automated urine reagent strip tests are cost-effective for detecting albuminuria.
- The influence of urinary tract infections (UTIs) on the accuracy of these tests is not well-established.
Purpose of the Study:
- To assess the impact of UTIs on albuminuria diagnosis using both biochemical and automated test strip methods.
- To compare the accuracy of the Fully Automatic Urine Chemistry Analyzer (UC-3500) in diagnosing albuminuria during and after UTI treatment.
Main Methods:
- Prospective collection of urine samples from adult female UTI patients before and after cephalexin treatment.
- Urine culture, routine urinalysis, and albuminuria diagnosis via biochemical quantitative method and UC-3500.
- Albuminuria defined as urine albumin to creatinine ratio (UACR) ≥ 30 mg/g.
Main Results:
- Among 54 patients, 44.44% had transient albuminuria during UTI.
- Quantitative UACR significantly decreased post-treatment (median 53 mg/g to 9 mg/g).
- UC-3500 showed higher false positive rates during UTI (42%) vs. post-treatment (19%), with moderate to good agreement with the quantitative method.
Conclusions:
- UTIs influence the accuracy of automated urine reagent strip tests for albuminuria.
- UTIs can cause transient albuminuria or false positive results with test strips.
- Excluding or treating UTIs is recommended before using automated tests for albuminuria screening.
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