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Related Experiment Video

Updated: Jun 16, 2026

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Structural and Functional Changes in Non-Paraneoplastic Autoimmune Retinopathy.

Amir Akhavanrezayat¹, Anadi Khatri^1,2,3, Neil Gregory L Onghanseng^1,4

¹Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, 2370 Watson Court, Palo Alto, CA 94303, USA.

Diagnostics (Basel, Switzerland)

|November 14, 2023

Summary

Multimodal imaging effectively detects longitudinal changes in non-paraneoplastic autoimmune retinopathy (npAIR). Adaptive optics scanning laser ophthalmoscopy (AOSLO) shows promise for monitoring retinal microstructure in npAIR patients.

Keywords:

AIR AOSLO GVF Goldmann visual field adaptive optics functional changes microperimetry non-paraneoplastic autoimmune retinopathy retina imaging structural changes

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Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Area of Science:

Ophthalmology
Retinal Diseases
Autoimmune Disorders

Background:

Non-paraneoplastic autoimmune retinopathy (npAIR) is a rare condition affecting vision.
Understanding the longitudinal progression of npAIR is crucial for patient management.

Purpose of the Study:

To describe longitudinal changes in patients with npAIR.
To evaluate the utility of various diagnostic modalities in monitoring npAIR progression.

Main Methods:

Retrospective longitudinal review of 16 eyes from 8 npAIR patients.
Utilized multimodal imaging: WAFP, WAFAF, SD-OCT, GVF, MP, electrophysiology, and AOSLO.

Main Results:

All patients showed anomalies at baseline across multiple tests.
AOSLO demonstrated superior ability to detect microstructural deterioration over time.
Functional deterioration was noted in GVF, MP, and mf-ERG during follow-up.

Conclusions:

Multimodal imaging aids in diagnosing and monitoring npAIR.
Assessing both anatomical and functional changes aids early detection.
AOSLO offers high-resolution imaging for quantifiable retinal microstructure changes in npAIR.