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Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives
Jiaxin Wang1,2, Lida Ren1,2, Xinqi Liu1,2
1Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
International Journal of Molecular Sciences
|November 14, 2023
Summary
Underactive bladder (UAB) and detrusor underactivity (DU) are common conditions lacking research. Recent advances clarify UAB/DU diagnosis and show promise in novel treatments like drugs, electrical stimulation, and stem cell therapy.
Area of Science:
- Urology
- Lower Urinary Tract Symptoms
- Bladder Dysfunction
Background:
- Underactive bladder (UAB) is a prevalent lower urinary tract symptom often associated with detrusor underactivity (DU).
- Significant knowledge gaps exist in UAB/DU pathophysiology, diagnosis, and treatment compared to overactive bladder (OAB).
- Clinicians have historically considered UAB/DU an incurable condition due to these gaps.
Purpose of the Study:
- To summarize recent advancements in understanding Underactive Bladder (UAB) and Detrusor Underactivity (DU).
- To highlight updated definitions and diagnostic criteria for UAB and DU.
- To review emerging diagnostic methods and promising therapeutic strategies for UAB/DU.
Main Methods:
- Review of recent scientific literature on UAB and DU.
- Analysis of updated definitions and diagnostic criteria by the International Continence Society (ICS).
- Evaluation of clinical trial data for novel treatments.
Main Results:
- Improved clarity on UAB definition and more comprehensive DU diagnostic criteria.
- Development and reporting of non-invasive diagnostic methods for UAB/DU.
- Promising outcomes from clinical trials involving new drugs, electrical stimulation, and stem cell therapy.
Conclusions:
- Recent research has significantly improved the understanding of UAB and DU.
- Novel diagnostic and therapeutic approaches offer new hope for managing UAB/DU.
- Further research is warranted to fully elucidate and treat these common bladder conditions.
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