Related Experiment Video
Updated: Jul 11, 2025
07:59
Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
1.1K
ZNF714 Supports Pro-Oncogenic Features in Lung Cancer Cells
Urszula Oleksiewicz1,2, Marta Machnik1,2, Joanna Sobocińska1,2
1Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, 8 Rokietnicka Street, 60-806 Poznan, Poland.
International Journal of Molecular Sciences
|November 14, 2023
Summary
Zinc Finger Protein 714 (ZNF714) is overexpressed in many cancers, promoting tumor growth and invasion. This study reveals ZNF714
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Cancer remains a significant global health threat.
- Krüppel-associated box zinc finger proteins (KRAB-ZNF) are implicated in carcinogenesis.
- Zinc Finger Protein 714 (ZNF714) is a KRAB-ZNF gene overexpressed in tumors with unknown function.
Purpose of the Study:
- To investigate the oncogenic role of ZNF714 in cancer.
- To explore the regulatory mechanisms and functional impact of ZNF714 overexpression.
Main Methods:
- Pan-cancer analysis using The Cancer Genome Atlas (TCGA) databases.
- Functional studies including transcriptomic and methylomic profiling.
- In vitro experiments with ZNF714 knockdown in cancer cells.
Main Results:
- Confirmed frequent ZNF714 overexpression across multiple tumor types.
- Identified ZNF714 overexpression correlates with tumor immunosuppression, proliferation, migration, and invasion.
- Demonstrated ZNF714 indirectly downregulates tumor suppressor genes (TSGs) via promoter methylation.
Conclusions:
- ZNF714 exhibits pro-oncogenic features, potentially supporting tumor progression in lung cancer.
- The precise regulatory mechanisms of ZNF714 require further investigation due to its lack of nuclear localization in the model.
- ZNF714 represents a potential target for cancer therapy.
Related Concept Videos
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
02:26NF-κB-dependent Signaling Pathway
7.5K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.5K
01:33Cancer-Critical Genes I: Proto-oncogenes
8.9K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.9K
01:12Loss of Tumor Suppressor Gene Functions
4.8K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.8K
02:53Adaptive Mechanisms in Cancer Cells
5.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K
01:20The Retinoblastoma Gene
4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K