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Perilla-Leaf-Derived Extracellular Vesicles Selectively Inhibit Breast Cancer Cell Proliferation and Invasion.

Do Kyung Kim¹, Su Jin Kang¹, Won Jong Rhee^1,2,3

¹Department of Bioengineering and Nano-Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.

International Journal of Molecular Sciences

|November 14, 2023

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Extracellular vesicles from perilla leaves (Perex) show potent, selective anti-cancer activity against breast cancer cells. This discovery offers a promising, cost-effective therapeutic alternative with reduced side-effects.

Area of Science:

Biotechnology
Nanomedicine
Cancer Therapeutics

Background:

Breast cancer presents significant mortality, with chemotherapy causing adverse effects due to lack of selectivity.
Extracellular vesicles (EVs) from cell cultures show anti-cancer potential but are limited by low productivity and high costs.
Developing novel, cost-effective, and selective cancer therapeutics is crucial.

Purpose of the Study:

To investigate the anti-cancer properties of extracellular vesicles derived from perilla leaves (Perex).
To assess the efficacy and selectivity of Perex against various cancer cells, particularly MDA-MB-231 breast cancer cells.
To evaluate Perex as a potential therapeutic agent for breast cancer treatment.

Main Methods:

High-purity Perex was isolated using ultrafiltration and size-exclusion chromatography.

Keywords:

Perex breast cancer caveolin-1 extracellular vesicle perilla leaf

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The anti-cancer activity of Perex was evaluated by assessing its effects on cancer cell proliferation, migration, and invasion.

Selective targeting of cancer cells with high caveolin-1 expression was analyzed.

Main Results:

Perex was successfully purified with high concentration and low impurities.
Perex demonstrated potent inhibition of proliferation, migration, and invasion in MDA-MB-231 breast cancer cells.
Perex selectively targeted cancer cells expressing high levels of caveolin-1, minimizing effects on normal cells.

Conclusions:

Perex exhibits significant, selective anti-cancer activity against breast cancer cells.
The high productivity and low cost of Perex production make it a promising therapeutic candidate.
Perex offers a potential alternative to conventional chemotherapy with reduced side-effects for breast cancer treatment.