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Lack of Association between Serum Chitotriosidase Activity and Arterial Stiffness in Type 2 Diabetes without

Luca D'Onofrio1, Rocco Amendolara1, Carmen Mignogna1

  • 1Department of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.

International Journal of Molecular Sciences
|November 14, 2023
PubMed

Insights

Chitotriosidase (CHIT) activity was not associated with arterial stiffness in people with type 2 diabetes (T2D) without cardiovascular disease (CVD). This study explored CHIT as a potential early biomarker for arterial stiffness in T2D.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Cardiovascular Research

Background:

  • Chitotriosidase (CHIT) levels are elevated in cardiovascular disease (CVD) and type 2 diabetes (T2D).
  • Arterial stiffness is an early indicator of CVD risk, particularly in individuals with T2D.
  • The potential of CHIT as an early biomarker for arterial stiffness in T2D requires investigation.

Purpose of the Study:

  • To assess chitotriosidase (CHIT) activity as an early biomarker for arterial stiffness.
  • To evaluate CHIT activity in individuals with type 2 diabetes (T2D) but without overt vascular complications.

Main Methods:

  • Cross-sectional study involving 174 individuals with T2D and no established CVD.
  • Arterial stiffness measured using pulse wave velocity (PWV).
  • CHIT serum activity quantified via electrochemiluminescence assay in high-PWV and low-PWV subgroups.

Main Results:

  • No significant difference in CHIT activity was observed between high-PWV and low-PWV groups.
  • High-PWV participants were older, had longer diabetes duration, higher blood pressure, glucose, HbA1c, and lower eGFR and BMI compared to the low-PWV group.
  • No association was found between CHIT activity and age, sex, diabetes duration, BMI, blood pressure, or medications.

Conclusions:

  • Chitotriosidase (CHIT) activity does not appear to be a reliable early biomarker for arterial stiffness in individuals with type 2 diabetes (T2D) without established cardiovascular disease (CVD).
  • This study provides novel data on the relationship between CHIT activity and arterial stiffness, a specific CVD outcome, in a well-defined T2D population.
  • Further research may be needed to explore other potential roles of CHIT in the context of diabetes and vascular health.

Keywords:
arterial stiffnesscardiovascular diseasechitotriosidasepulse wave velocitytype 2 diabetes

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