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Monoterpene Thiols: Synthesis and Modifications for Obtaining Biologically Active Substances
Denis V Sudarikov1, Liliya E Nikitina2, Patrick Rollin3
1Institute of Chemistry, Federal Research Center "Komi Scientific Center", Ural Branch, Russian Academy of Sciences, 167000 Syktyvkar, Russia.
Abstract:
Monoterpene thiols are one of the classes of natural flavors that impart the smell of citrus fruits, grape must and wine, black currants, and guava and are used as flavoring agents in the food and perfume industries. Synthetic monoterpene thiols have found an application in asymmetric synthesis as chiral auxiliaries, derivatizing agents, and ligands for metal complex catalysis and organocatalysts. Since monoterpenes and monoterpenoids are a renewable source, there are emerging trends to use monoterpene thiols as monomers for producing new types of green polymers. Monoterpene thioderivatives are also known to possess antioxidant, anticoagulant, antifungal, and antibacterial activity. The current review covers methods for the synthesis of acyclic, mono-, and bicyclic monoterpene thiols, as well as some investigations related to their usage for the preparation of the compounds with antimicrobial properties.
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