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Primary Hyperparathyroidism and Cardiovascular Disease: An Association Study Using Clinical Natural Language
Pedro Iglesias1,2, Javier Arias3, Guillermo López3
1Department of Endocrinology and Nutrition, Hospital Universitario Puerta de Hierro Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro Segovia de AranaMajadahonda, 28222 Madrid, Spain.
Journal of Clinical Medicine
|November 14, 2023
Summary
Primary hyperparathyroidism (PHPT) is linked to increased cardiovascular risk factors and diseases. This study confirms a significant association between PHPT and major cardiovascular issues in a large patient population.
Area of Science:
- Endocrinology
- Cardiology
- Public Health
Background:
- Primary hyperparathyroidism (PHPT) is a condition with potential links to cardiovascular diseases (CVDs).
- Understanding these associations is crucial for patient management and risk stratification.
- Previous studies suggest a connection, but large-scale data analysis is needed.
Purpose of the Study:
- To evaluate the association between primary hyperparathyroidism (PHPT) and major cardiovascular risk factors (CVRFs).
- To assess the relationship between PHPT and various cardiovascular diseases (CVDs).
- To utilize artificial intelligence (AI) tools for data analysis in this evaluation.
Main Methods:
- An observational, retrospective study using electronic health records (EHRs).
- Inclusion of 699,157 adult patients, with a focus on 6515 diagnosed with PHPT.
- Multivariate regression analysis to determine independent associations.
Main Results:
- Patients with PHPT showed significantly higher frequencies of hypertension, dyslipidemia, diabetes mellitus, and smoking.
- The incidence of stroke, ischemic heart disease, atrial fibrillation, deep vein thrombosis, and pulmonary embolism was significantly higher in the PHPT cohort.
- PHPT was independently associated with all evaluated CVDs (p < 0.001).
Conclusions:
- Primary hyperparathyroidism is significantly associated with major cardiovascular risk factors.
- A strong, independent link exists between PHPT and a range of cardiovascular diseases.
- These findings highlight the importance of cardiovascular monitoring in patients with PHPT.
Keywords:
atrial fibrillationdiabetes mellitusdyslipidemiahypertensionischemic heart diseaseprimary hyperparathyroidismsmoking habitstrokeMore Related Videos
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