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Related Experiment Video

Updated: Jul 11, 2025

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Titanium-Dioxide-Nanoparticle-Embedded Polyelectrolyte Multilayer as an Osteoconductive and Antimicrobial Surface

Matthew Rothpan¹, Nitin Chandra Teja Dadi², Geoffrey McKay³

¹Department of Biomedical Engineering, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3A 2B6, Canada.

Materials (Basel, Switzerland)

|November 14, 2023

Summary

Researchers developed a novel bioactive coating for orthopedic implants using chitosan, alginate, and nanoparticles. This coating shows promising antibacterial and bone-growth-promoting properties, with titanium dioxide nanoparticles being less toxic than silver nanoparticles.

Keywords:

antibiofilm coating bioactive coating layer by layer orthopedic implants polyelectrolyte silver nanoparticles titanium dioxide nanoparticles

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Last Updated: Jul 11, 2025

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

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Published on: July 1, 2013

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Published on: April 11, 2020

Plasma Polishing as a New Polishing Option to Reduce the Surface Roughness of Porous Titanium Alloy for 3D Printing

Plasma Polishing as a New Polishing Option to Reduce the Surface Roughness of Porous Titanium Alloy for 3D Printing

Published on: April 28, 2023

Area of Science:

Biomaterials Science
Orthopedic Surgery
Nanotechnology

Background:

Bioactive surface coatings are crucial for orthopedic implants, especially for preventing infections.
Metal nanoparticles (mNPs) offer significant potential for antibacterial applications on implants.

Purpose of the Study:

To create a polyelectrolyte multilayer coating on porous titanium implants.
To incorporate silver nanoparticles (AgNPs) or titanium dioxide nanoparticles (TiO2NPs) for enhanced functionality.
To evaluate the antibacterial and osteoconductive properties of the developed coatings.

Main Methods:

Layer-by-layer (LbL) self-assembly of chitosan and alginate.
Incorporation and characterization of AgNPs and TiO2NPs using QCM-D, NTA, SEM, and AFM.
Assessment of cytotoxicity (AlamarBlue) and osteogenic differentiation (ALP activity).
Testing antibiofilm efficacy against Staphylococcus aureus.

Main Results:

Successful application of LbL polyelectrolyte coating on titanium implants.
Observed dose-dependent antibacterial and osteogenic effects.
TiO2NP coatings demonstrated lower cytotoxicity compared to AgNP coatings while maintaining antimicrobial activity.

Conclusions:

The study presents a proof-of-concept for a novel coating strategy for orthopedic implants.
The developed coatings exhibit both antimicrobial and osteoconductive potential.
TiO2NPs represent a promising alternative to AgNPs for orthopedic implant coatings due to reduced cytotoxicity.