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Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury

Viacheslav V Andrianov1,2, Vladimir A Kulchitsky3, Guzel G Yafarova1,2

  • 1Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, 420000 Kazan, Russia.

Molecules (Basel, Switzerland)
|November 14, 2023
PubMed

Keywords:
brain strokecooperelectron paramagnetic resonancenitric oxidespinal cord injury

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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