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Updated: Jul 11, 2025

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

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Published on: July 27, 2022

Gallium-Doped Hydroxyapatite: Shape Transformation and Osteogenesis Activity.

Wei Shuai^1,2, Jianguo Zhou³, Chen Xia⁴

¹School of Rehabilitation Medicine, Gannan Medical University, Ganzhou 341000, China.

Molecules (Basel, Switzerland)

|November 14, 2023

Summary

Gallium-doped hydroxyapatite (Ga-HAp) nanoparticles were synthesized, showing gallium inhibits crystal growth and alters morphology. Ga-HAp enhances bone marrow stem cell proliferation and differentiation.

Keywords:

gallium hydroxyapatite osteogenesis

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Last Updated: Jul 11, 2025

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Published on: September 11, 2015

Area of Science:

Materials Science
Biomaterials Engineering
Nanotechnology

Background:

Hydroxyapatite (HAp) is a key biomaterial for bone regeneration.
Controlling HAp nanoparticle morphology and properties is crucial for optimizing its biological performance.
Gallium doping presents a potential strategy to enhance HAp's therapeutic efficacy.

Purpose of the Study:

To synthesize gallium-doped hydroxyapatite (Ga-HAp) nanoparticles using chemical precipitation.
To investigate the effect of gallium ion concentration on HAp crystal growth, morphology, and ion release.
To evaluate the in vitro biological response of Ga-HAp on bone marrow mesenchymal stem cells.

Main Methods:

Chemical precipitation method for Ga-HAp nanoparticle synthesis.
Modulation of gallium ion concentration to control microstructure.
Characterization of crystal growth, morphology, and ion substitution.
In vitro cell culture experiments with bone marrow mesenchymal stem cells.

Main Results:

Gallium ions significantly inhibit HAp crystal growth in a dose-dependent manner.
Gallium doping induces a morphological transition from nanoneedles to nanosheets.
Maximum calcium ion substitution by gallium in HAp lattice is limited to 4.85%.
Gallium doping effectively constrains ion release from HAp nanoparticles.
Ga-HAp significantly enhances proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells.

Conclusions:

Gallium doping is an effective strategy to tailor HAp nanoparticle properties for enhanced biomaterial applications.
Ga-HAp demonstrates promising potential for promoting bone regeneration by stimulating stem cell activity.
The controlled inhibition of crystal growth and ion release by gallium offers new avenues for biomaterial design.