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Smart Responsive Microneedles for Controlled Drug Delivery
Zhenzhen Qi1, Zheng Yan1, Guohongfang Tan1
1National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China.
Molecules (Basel, Switzerland)
|November 14, 2023
Summary
Smart responsive polymer microneedles offer painless, precise drug delivery for various diseases. This review highlights their on-demand release mechanisms and future research directions in transdermal drug administration.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Microneedles represent an emerging technology for painless and self-administered transdermal drug delivery.
- Effective regulation of drug release from polymer microneedles is crucial for transdermal therapies.
- Intelligent responsive microneedles enable on-demand, localized drug release triggered by internal or external stimuli.
Purpose of the Study:
- To review recent advancements in smart responsive polymer microneedles.
- To summarize various stimulus-responsive mechanisms and their applications.
- To highlight the potential of these systems in targeted transdermal drug delivery.
Main Methods:
- Literature review of recent research on smart responsive polymer microneedles.
- Analysis of different stimuli-responsive mechanisms (e.g., pH, temperature, light).
- Examination of application scenarios in disease treatment and wound repair.
Main Results:
- Identified diverse stimuli-responsive strategies for microneedle drug release.
- Demonstrated the potential for precise and localized drug delivery.
- Highlighted applications in treating diabetes, tumors, and promoting wound healing.
Conclusions:
- Innovative responsive microneedle systems provide a convenient and precise method for targeted drug delivery.
- Significant research implications exist for transdermal drug administration.
- Future research will focus on ensuring safety and efficacy for clinical translation.
