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Splicing across adipocyte differentiation is highly dynamic and impacted by metabolic phenotype
Marcelo Nobrega1, Kathryn Farris1, Emil Andersen2
1University of Chicago.
Alternative splicing dynamically regulates adipocyte differentiation and function, independent of gene expression changes. This mechanism is crucial for understanding metabolic disease risk in obesity and type 2 diabetes.
Area of Science:
- Metabolic disease
- Gene regulation
- Adipocyte biology
Background:
- Obesity-associated metabolic complications stem from adipose tissue dysfunction.
- Understanding gene regulation in unhealthy adipose tissue is key to uncovering dysfunction mechanisms.
- Alternative splicing's role in adipocyte differentiation and function remains underexplored.
Conclusions:
- Alternative splicing is a critical, independent gene regulatory mechanism in adipocyte differentiation.
- Splicing alterations in early differentiation correlate with genetic risk for type 2 diabetes.
- Findings offer insights into metabolic disease pathogenesis and guide future variant-to-function studies.
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