Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

6.1K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.1K
The Proteasome01:13

The Proteasome

855
Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
855

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differences in coronary disease severity at time of acute coronary syndrome between Middle East and North America.

Cardiovascular diagnosis and therapy·2026
Same author

Association of bidi smoking and tobacco-use patterns with cancer risk in India: a multicentre unmatched case-control study (2024-2025).

The Lancet regional health. Southeast Asia·2026
Same author

Incidental Radiation Exposure to the Internal Mammary Lymph Nodes in Breast Cancer Patients Undergoing Intensity-Modulated Radiation Therapy: A Retrospective Analysis.

The Gulf journal of oncology·2026
Same author

Disruption to TFEB signaling and autophagy in newly formed oligodendrocytes leads to aberrant generation of CNS myelin.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Actin dynamics: Filament end remodeling drives rapid depolymerization.

Current biology : CB·2026
Same author

Acute developmental exposure to doxycycline and sucrose alters retinal function in three commonly used mouse strains.

Experimental eye research·2026

Related Experiment Video

Updated: Jul 11, 2025

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

2.9K

Visual impairment cell non-autonomously dysregulates brain-wide proteostasis.

Shashank Shekhar1, Katherine J Wert2,3, Helmut Krämer1,3,4

  • 1Department of Neuroscience, UT Southwestern Medical Center; Dallas, TX.

Biorxiv : the Preprint Server for Biology
|November 14, 2023
PubMed
Summary

Loss of vision or hearing is linked to dementia risk. Sensory deprivation triggers brain stress granules, impacting protein quality control, but this is reversible.

More Related Videos

Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina
09:03

Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina

Published on: February 13, 2021

4.3K
Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
10:50

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

7.7K

Related Experiment Videos

Last Updated: Jul 11, 2025

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

2.9K
Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina
09:03

Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina

Published on: February 13, 2021

4.3K
Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
10:50

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

7.7K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Hearing and vision loss are dementia risk factors, but the molecular links remain unclear.
  • Cellular stress responses, particularly protein quality control, are crucial for brain health.

Approach:

  • Investigated Drosophila models of blindness to study brain responses.
  • Examined stress granule formation and reversal upon vision restoration.
  • Analyzed stress granule components (p62, ATF4, XRP1) and their role in gene expression.

Key Points:

  • Non-autonomous induction of stress granules in the brain upon vision loss in Drosophila.
  • Stress granules sequester transcription factors (ATF4, XRP1), dampening downstream gene expression.
  • Similar stress granule markers (p62, ATF4) observed in the brains of blind mouse models.

Conclusions:

  • Sensory input loss dysregulates brain stress responses, affecting protein quality control.
  • The link between sensory deprivation and altered stress granule dynamics is conserved across species.
  • These findings offer insights into molecular mechanisms connecting sensory deficits and dementia risk.