Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

55.3K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
55.3K
Long-term Depression01:03

Long-term Depression

2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.5K
Analgesia and Pain Management01:25

Analgesia and Pain Management

634
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
634
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

206
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
206

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The human claustrum supports cognitive networks for externally and internally driven task demands.

PLoS biology·2026
Same author

Understanding Motor Adaptation in the Transition to Sustained Pain: Protocol for a Longitudinal Experimental Study.

JMIR research protocols·2026
Same author

Hypermobility and chronic pain in adolescents: diverging functional and neural profiles without sensory differences.

Pain·2026
Same author

A Beta-Binomial Model for Estimating Zero- or One-inflated Pain Trajectories.

bioRxiv : the preprint server for biology·2026
Same author

The Endocannabinoid System's Contribution to Placebo Analgesia.

bioRxiv : the preprint server for biology·2026
Same author

Peripheral capsaicin reverses nerve injury-associated maladaptive brain networks in male rats: a simultaneous chemogenetic-functional magnetic resonance imaging study.

Pain·2026

Related Experiment Video

Updated: Jul 11, 2025

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.2K

Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain.

Brent W Stewart1, Michael L Keaser1, Hwiyoung Lee2

  • 1Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.

Biorxiv : the Preprint Server for Biology
|November 14, 2023
PubMed
Summary

The claustrum, a brain region, is active during pain and shows abnormal function in migraine patients, potentially causing cognitive issues. This study reveals a new brain circuit linked to chronic pain and cognitive deficits.

Keywords:
Chronic painClaustrumCognitionCognitive controlMigraineNetworksPain

More Related Videos

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.3K
Monitoring Acupuncture Effects on Human Brain by fMRI
09:55

Monitoring Acupuncture Effects on Human Brain by fMRI

Published on: April 8, 2010

15.5K

Related Experiment Videos

Last Updated: Jul 11, 2025

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.2K
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.3K
Monitoring Acupuncture Effects on Human Brain by fMRI
09:55

Monitoring Acupuncture Effects on Human Brain by fMRI

Published on: April 8, 2010

15.5K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Pain Research

Background:

  • Chronic pain is linked to cognitive network dysfunction.
  • The precise mechanisms and brain regions involved in pain-related cognitive deficits remain unclear.
  • The claustrum's role in cognitive network modulation warrants further investigation.

Conclusions:

  • The claustrum plays a role in modulating cognitive networks during acute pain.
  • Aberrant claustrum-latDLPFC circuit activity and connectivity may underlie cognitive deficits in chronic pain conditions like migraine.
  • These findings highlight a potential neural substrate for cognitive impairments in chronic pain.