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Aberrant splicing in Huntington's disease via disrupted TDP-43 activity accompanied by altered m6A RNA modification

Thai B Nguyen, Ricardo Miramontes, Carlos Chillon-Marinas

    Biorxiv : the Preprint Server for Biology
    |November 14, 2023
    PubMed
    Summary

    Huntington's disease (HD) involves altered RNA processing due to CAG repeat expansion. This study reveals TDP-43 dysfunction and reduced m6A modification as key mechanisms disrupting gene splicing in HD.

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