Estimating multimodal brain variability in schizophrenia spectrum disorders: A worldwide ENIGMA study

Area of Science:

• Neuroimaging
• Psychiatry
• Neuroscience

Background:

• Schizophrenia is a complex brain disorder characterized by significant structural heterogeneity.
• Understanding this heterogeneity is crucial for identifying schizophrenia subtypes and biomarkers.
• Current knowledge of structural brain variability in schizophrenia remains incomplete.

Conclusions:

• Elevated frontotemporal heterogeneity may indicate distinct schizophrenia subtypes converging on impaired frontotemporal interaction.
• Homogeneous folding in the left parahippocampal region might represent a shared characteristic across schizophrenia subtypes.
• Structural brain variability is vital for advancing neurobiological understanding and identifying biomarkers for schizophrenia.