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Related Experiment Video

Updated: Jul 11, 2025

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
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Characterization of an Osmr Conditional Knockout Mouse Model.

Logan S Schwartz1,2, Ruth L Saxl1, Tim Stearns1

  • 1The Jackson Laboratory, Bar Harbor, ME, USA.

Biorxiv : the Preprint Server for Biology
|November 14, 2023
PubMed
Summary
This summary is machine-generated.

This study investigated Oncostatin M receptor (OSMR) signaling in adult hematopoiesis using a conditional knockout mouse model. Results show variable impacts on OSMR mRNA and protein expression across tissues, cautioning its use.

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Area of Science:

  • Immunology
  • Hematopoiesis
  • Molecular Biology

Background:

  • Oncostatin M (OSM) is an IL-6 family cytokine with dual roles.
  • OSM signaling involves receptor complexes including OSMRβ.
  • Understanding OSM-OSMRβ in adult hematopoiesis is crucial.

Conclusions:

  • The B6;129-Osmr/J conditional mouse model exhibits tissue-dependent effects on Osmr mRNA and protein expression.
  • Caution is advised when using this model due to variable gene deletion efficiency and downstream signaling impact.
  • Further characterization is needed to fully understand OSM-OSMRβ signaling in adult hematopoiesis.