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Systems genetics approaches for understanding complex traits with relevance for human disease
Hooman Allayee1,2, Charles R Farber3,4,5, Marcus M Seldin6
1Departments of Population & Public Health Sciences, University of Southern California, Los Angeles, United States.
Elife
|November 14, 2023
Summary
Systems genetics integrates intermediate phenotypes to study complex traits, linking DNA to health outcomes. This review highlights resources and tools for researchers in human and rodent models.
Area of Science:
- Genetics
- Systems Biology
- Bioinformatics
Background:
- Complex traits arise from multiple genetic loci and environmental factors.
- Systems genetics bridges DNA variation with clinical phenotypes using intermediate molecular data.
- Understanding these links is crucial for medical research and disease understanding.
Conclusions:
- Systems genetics offers a powerful framework for dissecting complex traits.
- Accessible resources and tools are vital for advancing the field.
- This review aims to empower researchers with practical data and methods.
Keywords:
complex traitscomputational biologygeneticsgenomicshuman populationsmouse modelsomicssystems biologysystems geneticsMore Related Videos
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