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Published on: March 30, 2014
Isavuconazole use and TDM in real-world pediatric practice
Berta Fernández Ledesma1, Natalia Mendoza-Palomar1, Susana Melendo Pérez1
1Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Infantil. Vall d'Hebron Barcelona Hospital Campus, Institut de Recerca Vall d'Hebron, Barcelona, Catalonia, Spain.
Abstract:
Isavuconazole (ISA) is approved for treating invasive aspergillosis and mucormycosis in adults, but its use in children remains off-label. We report on the use of ISA in real-world pediatric practice with 15 patients receiving ISA for treatment of invasive fungal infections. Therapeutic drug monitoring (TDM) was performed in all patients, with 52/111 (46.8%) Ctrough determinations out of range, thus supporting the need for TDM in children, especially those receiving extracorporeal membrane oxygenation (ECMO).
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