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Genomic DNA in Eukaryotes

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Related Experiment Video

Updated: Jul 11, 2025

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

Published on: May 31, 2011

ELM-the Eukaryotic Linear Motif resource-2024 update.

Manjeet Kumar¹, Sushama Michael¹, Jesús Alvarado-Valverde^1,2

¹Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.

Nucleic Acids Research

|November 14, 2023

Summary

This summary is machine-generated.

The Eukaryotic Linear Motif (ELM) Resource database has been updated with 39 new motif classes and 346 instances. This update enhances understanding of protein regulation and pathogen interactions for biomedical researchers.

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Last Updated: Jul 11, 2025

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

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An Integrated Approach for Microprotein Identification and Sequence Analysis

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Area of Science:

* Molecular Biology
* Bioinformatics
* Structural Biology

Background:

* Short Linear Motifs (SLiMs) are crucial for eukaryotic protein function and regulation.
* SLiMs are abundant, especially with post-translational modifications, and are targeted by pathogens.
* The Eukaryotic Linear Motif (ELM) Resource provides a curated database of SLiMs.

Purpose of the Study:

* To report the 2024 update of the ELM Resource database.
* To highlight the newly annotated motif instances and classes.
* To integrate ELM data with other protein resources like InterPro.

Main Methods:

* Manual curation of SLiM instances from scientific literature.
* Annotation by a community of skilled annotators.
* Integration of data with the InterPro protein module resource.

Main Results:

* The 2024 ELM update adds 39 new motif classes and 346 novel motif instances.
* The database now contains 356 motif classes and 4283 instances from 4274 publications.
* Over 700 links to experimentally determined 3D structures are included.

Conclusions:

* The updated ELM Resource expands knowledge of SLiM functionality in areas like immunity and degradation.
* Enhanced data facilitates biomedical research into protein regulation and pathogen mimicry.
* Integration with InterPro increases the discoverability and utility of ELM data.