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Updated: Jul 11, 2025

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

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The effects of tranexamic acid on platelets in patients undergoing cardiac surgery: a systematic review and

Zhi-Yao Zou1, Li-Xian He1, Yun-Tai Yao2

  • 1Department of Anesthesiology, Fuwai Yunnan Cardiovascular Hospital, 650000, Kunming, Yunnan Province, China.

Journal of Thrombosis and Thrombolysis
|November 14, 2023
PubMed

Insights

Tranexamic acid (TXA) did not alter platelet counts in adult cardiac surgery patients but increased them in pediatric patients and adults undergoing valvular surgery. TXA also enhanced platelet function, specifically ADP-stimulated aggregation and CD63 expression.

Area of Science:

  • Hematology
  • Cardiovascular Surgery
  • Pharmacology

Background:

  • Platelet dysfunction and count reduction can occur post-cardiac surgery.
  • Tranexamic acid (TXA) is used to reduce bleeding but its effect on platelets requires further clarification.

Purpose of the Study:

  • To evaluate the impact of tranexamic acid (TXA) on platelet count, function, and membrane proteins in patients undergoing cardiac surgery (CS).

Main Methods:

  • A meta-analysis of 49 eligible randomized controlled trials was conducted.
  • Searches included major databases up to June 2022, with an update in January 2023.
  • Primary outcomes: platelet counts, function, and membrane proteins; Secondary outcome: postoperative bleeding.

Main Results:

  • TXA did not affect post-operative platelet counts in adult patients undergoing on- or off-pump CS.
  • TXA significantly increased post-operative platelet counts in pediatric patients undergoing on-pump CS and in adults undergoing valvular surgery.
  • TXA improved ADP-stimulated platelet aggregation and CD63 expression on platelets.

Conclusions:

  • TXA administration does not impact post-operative platelet counts in adult cardiac surgery patients but increases them in pediatric CS and adult valvular surgery patients.
  • TXA enhances platelet function, evidenced by improved ADP-stimulated aggregation and CD63 expression.
  • Further well-designed, adequately powered randomized trials are necessary to confirm these findings.

Keywords:
Cardiac surgeryPlateletsTranexamic acid

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