Correlations between clinical parameters, blastocyst morphological classification and embryo euploidy

Area of Science:

• Reproductive Medicine
• Embryology
• Genetics

Background:

• Assisted reproductive technologies (ART) rely on accurate embryo selection.
• Ploidy status is a critical factor influencing implantation and pregnancy outcomes.
• Predictive markers for embryo ploidy can optimize ART success rates.

Purpose of the Study:

• To identify clinical and embryo-derived parameters for predicting embryo ploidy.
• To compare characteristics of euploid versus aneuploid embryos.

Main Methods:

• Retrospective analysis of 838 day-5 blastocysts from 219 patients.
• Embryos classified morphologically and grouped by genetic test results (euploid vs. aneuploid).
• Comparison of maternal age, anti-Mullerian hormone (AMH), antral follicle count (AFC), and embryo morphology.

Main Results:

• Euploid embryos associated with significantly lower maternal age (36.2 vs. 37.1 years) and higher AMH levels (3.9 vs. 3.6 IU/L).
• Antral follicle count (AFC) did not significantly differ between euploid and aneuploid groups.
• Aneuploidy was negatively correlated with top embryo quality (4AA, 4AB); all euploid embryos were top quality versus 61.49% of aneuploid embryos.

Conclusions:

• Lower maternal age, higher AMH, and superior embryo morphology are predictive of euploidy.
• These factors can aid in selecting embryos with a higher likelihood of successful implantation.
• Further research may refine predictive models for embryo selection in ART.