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Related Concept Videos

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
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Development of Blood Vessels01:07

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The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
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Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye
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Structural Anomalies in Multifetal Gestations.

Elizabeth A Hoover1, Yasuko Yamamura1, Gwyneth Thompson2

  • 1Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, Minnesota.

Clinical Obstetrics and Gynecology
|November 14, 2023
PubMed
Summary
This summary is machine-generated.

Multifetal pregnancies have higher risks of structural anomalies than singletons, especially monochorionic twins. Counseling for these pregnancies requires a holistic approach, considering the entire pregnancy and shared decision-making.

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Area of Science:

  • Reproductive Medicine
  • Maternal-Fetal Medicine
  • Prenatal Diagnosis

Background:

  • Multifetal gestations, particularly twins, exhibit a higher incidence of structural anomalies compared to singleton pregnancies.
  • Chorionicity determination is crucial, as monochorionic pregnancies face the greatest risk.
  • Fetal anomalies in multifetal gestations necessitate complex counseling that addresses the entire pregnancy, unlike singleton cases.

Approach:

  • Reviewing the incidence of structural anomalies in twin gestations.
  • Highlighting unique considerations in managing multifetal anomalies, such as selective termination for discordant conditions.
  • Emphasizing the importance of shared decision-making between healthcare providers and patients.

Key Points:

  • Twin pregnancies have an increased risk of structural anomalies.
  • Monochorionic twins face the highest risk.
  • Counseling for multifetal anomalies requires a comprehensive approach, including options like selective termination.
  • Shared decision-making is vital for optimal patient care.

Conclusions:

  • Managing fetal anomalies in multifetal gestations demands specialized counseling strategies.
  • Selective termination is a key consideration for discordant anomalies in twins.
  • Provider-patient collaboration through shared decision-making enhances management of complex multifetal pregnancies.