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Updated: Jul 11, 2025
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A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions
Published on: February 5, 2016
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hROS-Responsive Behavior for Long-Term Stability of Cellulosic Gold Nanoclusters
Shanshan Yu1,2, Haoyuan Li1,2, Yujie Duan1,2
1School of Light Industry and Food Engineering, Guangxi University, Nanning, 530004, P. R. China.
Small (Weinheim an Der Bergstrasse, Germany)
|November 14, 2023
Summary
Researchers developed a bionic strategy using cellulose nanocrystals (CNCs) to stabilize gold nanoclusters (GNCs), enhancing their photoluminescence and creating sensitive disease diagnostic probes. This method improves GNC stability and allows for tailored responsiveness to reactive oxygen species.
Area of Science:
- Nanomaterials Science
- Biomimetic Chemistry
- Photochemistry
Background:
- Understanding gold core-ligand interactions is key for tuning gold nanocluster (GNC) photoluminescence and stability.
- Existing methods for GNC stabilization and functionalization require improvement for specific applications.
Purpose of the Study:
- To develop a novel, bionic strategy for stabilizing GNCs using cellulose nanocrystals (CNCs).
- To tailor GNCs for specific reactive oxygen species (ROS) responsiveness and create ratiometric probes for disease diagnosis.
- To investigate the influence of ligand structure on GNC photoluminescence and ROS response.
Main Methods:
- GNCs were synthesized and stabilized on carboxylated CNCs, inspired by octopus tentacle structures.
- Ligand structures were systematically varied to create ROS-responsive and nonresponsive GNCs.
- Photoluminescence properties, quantum yields, and stability of GNCs were characterized.
- Dual GNC ratiometric probes were constructed and tested for intracellular ROS imaging and disease diagnosis.
Main Results:
- Carboxylated CNCs provided an electron-rich environment, enhancing GNC luminescence and achieving long-term stability (1 year).
- The highest quantum yield reached 31.02% in ultrapure water.
- The bionic strategy was effective for various ligands, enabling tunable emission wavelengths and ROS responsiveness.
- A dual GNC ratiometric probe demonstrated a low limit of detection (0.74 µmol L⁻¹) for intracellular ROS imaging.
Conclusions:
- The bionic preparation strategy using CNCs offers an effective method for stabilizing GNCs and tailoring their properties.
- Ligand design is critical for controlling GNC oxidation and ROS-responsive characteristics.
- The developed dual GNC ratiometric probes show promise for sensitive intracellular ROS detection and disease diagnostics.
