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Updated: Jul 11, 2025

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Memory allocation at the neuronal and synaptic levels.

HyoJin Park1, Bong-Kiun Kaang2

  • 1Center for Cognition and Sociality, Life Science Institute, Institute for Basic Science (IBS), Daejeon 34126; Department of Biological Science, Seoul National University, Seoul 08826, Korea.

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Summary
This summary is machine-generated.

Memory allocation mechanisms store memories in neurons and synapses. Increased neuronal excitability via CREB and synaptic tagging are key processes influencing where and how memories are encoded.

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Area of Science:

  • Neuroscience
  • Cellular Biology
  • Molecular Biology

Background:

  • Memory allocation determines the precise location of memory storage within neurons or synapses.
  • Specific molecular and cellular mechanisms underlie memory allocation.

Approach:

  • This review summarizes fundamental concepts of memory allocation at both neuronal and synaptic levels.
  • It discusses the potential interrelationships between these two levels of memory allocation.

Key Points:

  • Neuronal allocation involves increased excitability, particularly through cAMP response element-binding protein (CREB), biasing memory encoding to specific neuron populations.
  • Synaptic allocation relies on synaptic tagging, allowing memory to be mediated by diverse synaptic strengthening mechanisms within a single neuron.

Conclusions:

  • Understanding memory allocation at neuronal and synaptic levels is crucial for deciphering memory formation and storage.
  • Further research into the interconnections between neuronal and synaptic allocation mechanisms will provide deeper insights into memory processes.