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Effect of corneal flap thickness on opaque bubble layer formation in Visumax FS-LASIK using GEE analysis
Na Zhou1, Xiaobei Chen1, Na Yin1
1Department of Refractive Surgery, Dongguan Aier Eye Hospital, China.
Introduction:
This study aimed to investigate two types of corneal flap thickness on opaque bubble layer (OBL) formation in Visumax femtosecond laser-assisted stromal for situ keratomileusis (FS-LASIK).
Methods:
This retrospective study analyzed 203 eyes of 103 patients (32 men and 71 women) who underwent Visumax FS-LASIK between January 2020 and June 2020, and according to corneal flap thickness, they were divided into the 100-μm group (64 eyes) and the 110-μm group (139 eyes). Anterior-segment examination revealed no abnormal findings. Preoperatively, intraocular pressure (IOP), central corneal thickness (CCT), residual stromal thickness (RST), spherical power, cylindrical power, flat keratometry (K1), steep keratometry (K2), and biomechanical parameters including deformation amplitude (DA) ratio, Integrated Radius, stiffness parameter at first applanation (SP-A1), and Ambrosio relational thickness to the horizontal profile (ARTh) were evaluated. Primary outcomes were the incidence of OBL formation in the two groups compared by the Chi-square test and the correlation between the incidence of OBL and the above preoperative data by Spearman's Rho test. Secondary outcomes were the comparisons corrected by the generalized estimating equation (GEE) model.
Results:
The incidence of OBL formation in the 100-μm group was 59.4 %, which was higher than that in the 110-μm group (23.0 %) with a significant difference (χ = 25.635, P < 0.001). The thinner corneal flap thickness (r = -0.355, P < 0.001) and higher spherical power (r = -0.142, P < 0.05) correlated with OBL formation. Higher K1 (r = 0.217, P < 0.01) and K2 (r = 0.198, P < 0.01) also correlated with OBL formation. The results of the GEE correction analysis showed higher rates of OBL formation in the 100-μm group (odds ratio [OR] = 4.704, 95 % CI 1.681-13.161, P < 0.01).
Conclusions:
OBL was more likely to occur with the 100-μm corneal flap than with the 110-μm corneal flap in Visumax FS-LASIK. The risk of OBL formation in the 100-μm group was 4.704 times higher than that in the 110-μm group.
