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Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling
10:00

Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling

Published on: October 28, 2014

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Cell type-specific translational regulation by human DUS enzymes.

Nathan J Yu, Wei Dai, Ang Li

    Biorxiv : the Preprint Server for Biology
    |November 15, 2023
    PubMed
    Summary

    Dihydrouridine (D) is a common tRNA modification, but its function in mammals is unclear. This study developed chemical probes to map D sites and found that losing D affects translation in a cell-specific way, impacting specific tRNAs.

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