Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

163
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
163
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

47
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
47
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

2.6K
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emerging Diagnostics Tools for Severe Male Infertility and Non-Obstructive Azoospermia.

Urology·2026
Same author

Lack of sustained improvements in erectile function following low-intensity extracorporeal shockwave therapy correlate with decreases in corporal brain-derived neurotropic factor: a pilot study and prospective clinical trial.

Sexual medicine·2026
Same author

Are We Overreporting Post-Op Sepsis? The Difference Between Reported and Verified Rates of Post-Ureteroscopy Sepsis Using the Sepsis 3 Criteria at a Single Institution.

Journal of endourology·2025
Same author

Prospective, Real-World Evaluation of CVAC 2.0 In-Scope Aspiration System Compared with Flexible and Navigable Ureteral Access Sheath for High-Volume Stone Disease.

Journal of endourology·2025
Same author

First in-vivo multicenter experience with the novel CVAC 2.0 ureteroscope with simultaneous irrigation and aspiration functionality.

World journal of urology·2025
Same author

Reply to Editorial Comment on "Stent or Treat: Predictors of Definitive Stone Management for Patients Presenting to the Emergency Department With Urolithiasis".

Urology·2025

Related Experiment Video

Updated: Jul 11, 2025

Author Spotlight: Effectiveness of Extracorporeal Shockwave Therapy in Achilles Tendinopathy Treatment
03:50

Author Spotlight: Effectiveness of Extracorporeal Shockwave Therapy in Achilles Tendinopathy Treatment

Published on: August 2, 2024

1.2K

Low-intensity shockwave therapy improves baseline erectile function: a randomized sham-controlled crossover trial.

Emmett H Kennady1, Darren J Bryk1, Marwan M Ali1

  • 1Department of Urology, University of Virginia, Charlottesville, VA 22903, United States.

Sexual Medicine
|November 15, 2023
PubMed
Summary
This summary is machine-generated.

Low-intensity shockwave therapy significantly improves erectile function in men with erectile dysfunction. This promising treatment option showed lasting effects for up to six months in a clinical trial.

Keywords:
Keywords: extracorporeal shockwave therapyerectile dysfunctionmale sexual impotencerandomized controlled trialsham treatment

More Related Videos

Transcranial Pulse Stimulation for Alzheimer's Patients
06:08

Transcranial Pulse Stimulation for Alzheimer's Patients

Published on: April 4, 2025

694

Related Experiment Videos

Last Updated: Jul 11, 2025

Author Spotlight: Effectiveness of Extracorporeal Shockwave Therapy in Achilles Tendinopathy Treatment
03:50

Author Spotlight: Effectiveness of Extracorporeal Shockwave Therapy in Achilles Tendinopathy Treatment

Published on: August 2, 2024

1.2K
Transcranial Pulse Stimulation for Alzheimer's Patients
06:08

Transcranial Pulse Stimulation for Alzheimer's Patients

Published on: April 4, 2025

694

Area of Science:

  • Urology
  • Andrology
  • Regenerative Medicine

Background:

  • Erectile dysfunction (ED) is a prevalent condition affecting male sexual health.
  • Low-intensity shockwave therapy (LIST) is an emerging, non-invasive treatment for ED.

Purpose of the Study:

  • To evaluate the efficacy of LIST in treating organic erectile dysfunction.
  • To compare LIST outcomes against a sham treatment in a randomized controlled trial.

Main Methods:

  • A randomized sham-controlled crossover trial involving 33 participants with organic ED.
  • Participants received either LIST or sham treatment for one month, with the sham group subsequently crossing over to LIST.
  • Efficacy was assessed using the Sexual Health Inventory for Men (SHIM) and Erection Hardness Score (EHS).

Main Results:

  • LIST significantly increased SHIM scores compared to sham treatment at one month (P=.024).
  • At six months, participants showed a mean SHIM score increase of 5.5 points (P<.001), with 54.6% achieving a clinically significant improvement.
  • 68% of men with baseline EHS <3 improved to EHS ≥3 at six months.

Conclusions:

  • Low-intensity shockwave therapy is effective in improving erectile function in men with ED.
  • The therapeutic benefits of LIST were observed to persist for at least six months post-treatment.