Related Experiment Video
Updated: Jul 11, 2025
Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
A Clinicopathologic Comparison Between Early-Onset and Late-Onset Small Bowel Adenocarcinoma: A Multicenter
Giovanni Arpa1,2, Alessandro Vanoli2, Francesca Antoci3
1Unit of Anatomic Pathology, ICS Maugeri-IRCCS SpA SB, Pavia, Italy.
Introduction:
Early-onset small bowel adenocarcinoma (EO-SBA) is a rare and poorly characterized entity.
Methods:
This retrospective study conducted on an international multicenter cohort of 208 patients with SBA aimed at comparing clinicopathologic features of EO-SBA (age younger than 50 years at SBA diagnosis) and late-onset SBA (age 50 years or older at SBA diagnosis).
Results:
The presence of predisposing pathologic conditions was significantly more common in the EO-SBA group compared with that in the late-onset SBA group ( P = 0.003, Fisher exact test; relative risk: 1.50, 95% confidence interval: 1.20-1.86). This difference is mainly due to the significantly higher prevalence of celiac disease among patients with EO-SBA.
Discussion:
EO-SBA is strongly associated with predisposing conditions, particularly with celiac disease, highlighting the importance of routine screening for celiac disease in patients with EO-SBA.
