Integrated Electrochemical and Optical Biosensing in Organs-on-Chip
Pratik Tawade1, Massimo Mastrangeli1
1Electronic Components, Technology and Materials, Department of Microelectronics, Delft University of Technology, Mekelweg 4, 2628CD, Delft, Netherlands.
Chembiochem : a European Journal of Chemical Biology
|November 15, 2023
Summary
Integrated biosensing offers precise, real-time monitoring for organs-on-chip, advancing drug testing and personalized medicine through electrical, electrochemical, and optical methods.
Area of Science:
- Biomedical Engineering
- Sensor Technology
- Organ-on-Chip Technology
Background:
- Growing demand for biocompatible, non-invasive, real-time monitoring in organs-on-chip.
- Limitations of current sensors in achieving highest accuracy and sensitivity for in vitro microenvironment analysis.
Purpose of the Study:
- To review integrated electrical, electrochemical, and optical sensing methods for organ-on-chip devices.
- To highlight advancements and challenges in biosensing integration for organ-on-chip technology.
Main Methods:
- Review of integrated electrical sensing methods.
- Review of integrated electrochemical sensing methods.
- Review of integrated optical sensing methods within organ-on-chip platforms.
Main Results:
- Integrated biosensing enables in situ monitoring of microenvironment and dynamic tissue responses.
- Precise detection of analytes and biochemical reactions enhances monitoring capabilities and reproducibility.
- These methods deepen the understanding of organ functions.
Conclusions:
- Integration of biosensing significantly advances organ-on-chip technology.
- Paves the way for applications in drug testing, disease modeling, and personalized medicine.
- Further research in biosensing integration is crucial for innovation.
