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Updated: Jul 11, 2025
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
[Developmental outcomes of very preterm and extremely preterm infants at the 12 months corrected age]
M P Yakovenko1, E I Kleshenko1, D A Kayumova1
1Kuban State Medical University, Krasnodar, Russia.
Insights
Cortexin combined with non-drug rehabilitation improved neurodevelopmental outcomes in preterm infants with pyramidal tract damage. This treatment strategy led to better outcomes compared to non-drug rehabilitation alone.
Area of Science:
- Neonatal Neurology
- Developmental Pediatrics
- Neurorehabilitation
Context:
- Preterm neonates, especially those with low and extremely low birth weight, are at risk for neurological impairments.
- Perinatal pyramidal tract (PT) damage is a significant concern affecting neurodevelopmental outcomes.
- Early intervention strategies are crucial for improving long-term prognosis in this vulnerable population.
Purpose:
- To evaluate the efficacy of Cortexin in conjunction with non-drug rehabilitation for preterm neonates with PT damage.
- To compare neurodevelopmental outcomes between infants receiving non-drug rehabilitation alone versus those receiving combined therapy.
- To assess the prognostic value of Diffusion Tensor Imaging (DTI) MRI in identifying infants at risk.
Summary:
- A study involving 127 preterm infants with PT damage compared outcomes of non-drug rehabilitation alone (Group I) versus combined non-drug rehabilitation and Cortexin (Group II).
- A control group (Group III) of 46 infants without structural changes on DTI MRI was also included.
- Neurodevelopmental outcomes were assessed at 12 months corrected age using the INFANIB scale.
Impact:
- Infants receiving Cortexin and non-drug rehabilitation showed significantly higher rates of normal neurodevelopment (40.7%) compared to those receiving non-drug rehabilitation alone (18.2%).
- The control group exhibited normal psychomotor development in 93.5% of cases.
- Cerebral palsy incidence was significantly lower in the Cortexin-treated group (13.6%) compared to the non-drug rehabilitation group (36.4%), highlighting Cortexin's potential benefits.
Objective:
To establish effect of Cortexin for development outcomes of preterm neonates born with low and extremely low body weight, with perinatal pyramidal tract (PT) damage.
Material And Methods:
127 children born with very low body weight and extremely low body weight were examined. I group - 22 infant with damage to the PT, treating non-drug rehabilitation during the first year. II group - 59 infant with damage to the PT, treating non-drug rehabilitation and Cortexin during the first year. III control group - 46 infant without structural changes according DTI MRI. Neurodevelopmental outcomes was evaluated by using the INFANIB scale at the 12 months corrected age.
Results:
Significant differences were found between groups. The results showed that at the correct age of 12 months normal neurodevelopment occurred more often in two times in second group (1 group - 18.2%, 2 group - 40.7%, p<0.05). Almost of children from control group had normal psychomotor development (3 group - 93.5%). Cerebral palsy was noted significantly more often in the first group (1 group - 36.4%, 3 group - 13.6%, p<0.05).
Conclusions:
DTI MRI has high prognostic value for very preterm and extremely preterm infants. In the same time, we can observe better development outcomes with damage to the PT in the group of children treating non-drug rehabilitation and Cortexin during the first year.
